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Product Name: fosfestrol
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522-40-7

522-40-7 structure

Name: fosfestrol
Chemical Name: [4-[(E)-4-(4-phosphonooxyphenyl)hex-3-en-3-yl]phenyl] dihydrogen phosphate
CAS Number: 522-40-7
Molecular Formula: C₁₈H₂₂O₈P₂
Molecular Weight: 428.31000
Create Date: 2018-08-13 10:52:28
Modify Date: 2024-01-06 20:10:31

Name	[4-[(E)-4-(4-phosphonooxyphenyl)hex-3-en-3-yl]phenyl] dihydrogen phosphate
Synonyms	ST52-Asta Stilbestrol diphosphate Fosfestrolum [INN-Latin] Phosphestrol Diethylstilbestryl diphosphate fosfestrol 3,4-Bis-(4-phosphonooxy-phenyl)-hex-3t-en Diethylstilbestrol diphosphate Phosphoestrolum Honvan Desdp 3,4-bis-(4-phosphonooxy-phenyl)-hex-3t-ene

Density	1.433g/cm3
Boiling Point	648.7ºC at 760mmHg
Molecular Formula	C₁₈H₂₂O₈P₂
Molecular Weight	428.31000
Flash Point	346.1ºC
Exact Mass	428.07900
PSA	153.14000
LogP	4.36040
Index of Refraction	1.609

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WJ5680000

CHEMICAL NAME :: 4,4'-Stilbenediol, alpha,alpha'-diethyl-, bis(dihydrogen phosphate), (E)-

CAS REGISTRY NUMBER :: 522-40-7

LAST UPDATED :: 199504

DATA ITEMS CITED :: 12

MOLECULAR FORMULA :: C18-H22-O8-P2

MOLECULAR WEIGHT :: 428.34

WISWESSER LINE NOTATION :: QPQO&OR DY2&UY2&R DOPQQO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 11 mg/kg/3D-I

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Blood - change in clotting factors Skin and Appendages - sweating

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 425 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 630 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 400 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 25 nmol/L

REFERENCE :: CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 40,817,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3653 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 9667 (estimated) No. of Female Employees: 7994 (estimated)

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522-40-7

Literature: Miles Labor. Inc. Patent: US2971975 , 1955 ; Full Text Show Details Asta-Werke Patent: GB732286 , 1952 ; Full Text Show Details Ciba Pharm. Prod. Inc. Patent: US2234311 , 1939 ; Full Text Show Details Ciba Patent: DE720468 , 1939 ; DRP/DRBP Org.Chem. Full Text Show Details Ciba Patent: CH219518 , 1938 ;

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