119356-77-3
119356-77-3 structure
- Name: Dapoxetine
- Chemical Name: Dapoxetine
- CAS Number: 119356-77-3
- Molecular Formula: C21H23NO
- Molecular Weight: 305.413
- Catalog: API Circulatory system medication Antihypertensive drug
- Create Date: 2018-08-24 16:59:02
- Modify Date: 2024-01-02 19:46:30
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Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].
| Name | Dapoxetine |
|---|---|
| Synonyms |
(1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine
Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, (αS)- Priligy Dapoxetina (1S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine Dapoxetine (1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine (+)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine (S)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine (1s)-n,n-dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine MFCD00865355 (S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine Dapoxetinum |
| Description | Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine. Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1] |
| In Vivo | Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2]. Animal Model: Adult male Wistar rats[2] Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Oral gavage; 1-10 mg/kg; once daily Result: Reverted most of the changes made by testosterone injection. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 454.4±38.0 °C at 760 mmHg |
| Molecular Formula | C21H23NO |
| Molecular Weight | 305.413 |
| Flash Point | 132.6±29.1 °C |
| Exact Mass | 305.177979 |
| PSA | 12.47000 |
| LogP | 5.13 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.607 |
| Storage condition | 2-8°C |
| HS Code | 2922199090 |
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| HS Code | 2922299090 |
|---|---|
| Summary | 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |