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  • DC Chemicals Limited
  • China
  • Product Name: Dapoxetine
  • Price: ¥Inquiry/100mg ¥Inquiry/250mg ¥Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 10 Day
  • Contact: Tony Cao

119356-77-3

119356-77-3 structure
119356-77-3 structure
  • Name: Dapoxetine
  • Chemical Name: Dapoxetine
  • CAS Number: 119356-77-3
  • Molecular Formula: C21H23NO
  • Molecular Weight: 305.413
  • Catalog: API Circulatory system medication Antihypertensive drug
  • Create Date: 2018-08-24 16:59:02
  • Modify Date: 2024-01-02 19:46:30
  • Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].

Name Dapoxetine
Synonyms (1S)-N,N-Dimethyl-3-(1-naphthyloxy)-1-phenyl-1-propanamine
Benzenemethanamine, N,N-dimethyl-α-[2-(1-naphthalenyloxy)ethyl]-, (αS)-
Priligy
Dapoxetina
(1S)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine
Dapoxetine
(1S)-N,N-dimethyl-3-naphthalen-1-yloxy-1-phenylpropan-1-amine
(+)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine
(S)-N,N-Dimethyl-a-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine
(1s)-n,n-dimethyl-3-(1-naphthyloxy)-1-phenylpropan-1-amine
MFCD00865355
(S)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine
Dapoxetinum
Description Dapoxetine (LY-210448) is an orally active and selective serotonin reuptake inhibitor (SSRI). Dapoxetine can be used for the research of premature ejaculation (PE)[1].
Related Catalog
In Vitro Dapoxetine binds to 5-HT, norepinephrine, and dopamine reuptake transporters and inhibits 5-HT, norepinephrine, and dopamine uptake with an order of potency: 5-HT >norepinephrine≫dopamine. Dapoxetine inhibits the uptake of [3H]5-HT by the 5-HT reuptake transporter with a value of 1.12 nM, and Dapoxetine inhibits the uptake of [3H]norepinephrine into cells utilizing the norepinephrine reuptake transporter and uptake of [3H]dopamine by the dopamine reuptake transporter with IC50 values of 202 nM and 1720 nM, respectively.[1]
In Vivo Dapoxetine (oral gavage; 1-10 mg/kg; once daily) significantly inhibits testosterone mediated increase in the prostate weight and relative prostate weight and attenuates testosterone-induced prostatic hyperplasia in rats[2]. Animal Model: Adult male Wistar rats[2] Dosage: 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Oral gavage; 1-10 mg/kg; once daily Result: Reverted most of the changes made by testosterone injection.
References

[1]. Muammer Kendirci, et al. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Ther Clin Risk Manag. 2007 Jun;3(2):277-89.

[2]. Rabab H Sayed, et al. Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins. Toxicol Appl Pharmacol. 2016 Nov 15;311:52-60.

Density 1.1±0.1 g/cm3
Boiling Point 454.4±38.0 °C at 760 mmHg
Molecular Formula C21H23NO
Molecular Weight 305.413
Flash Point 132.6±29.1 °C
Exact Mass 305.177979
PSA 12.47000
LogP 5.13
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.607
Storage condition 2-8°C
HS Code 2922199090
HS Code 2922299090
Summary 2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%