Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Urea,N,N'-bis(4-amino-2-methyl-6-quinolinyl)-, hydrochloride (1:2)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

5424-37-3

5424-37-3 structure

Name: Surfen
Chemical Name: 1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
CAS Number: 5424-37-3
Molecular Formula: C₂₁H₂₂Cl₂N₆O
Molecular Weight: 445.34
Catalog: Signaling Pathways Anti-infection HSV
Create Date: 2016-10-21 22:33:03
Modify Date: 2024-05-12 15:01:14
Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].

Name	1,3-bis(4-amino-2-methylquinolin-6-yl)urea, dihydrochloride
Synonyms	Aminoquincarbamide dihydrochloride Aminoquinuride hydrochloride

Description	Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and low molecular weight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HSV Research Areas >> Infection Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	FGFR2:5 μM (IC50) HSV-1
References	[1]. Schuksz M, et al. Surfen, a small molecule antagonist of heparan sulfate. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13075-80.

CHEMICAL NAME :: Urea, 1,3-bis(4-amino-2-methyl-6-quinolyl)-, dihydrochloride

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes

REFERENCE :: ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 2,581,1952