CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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UY7525000
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CHEMICAL NAME :
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3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, monosodium salt
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CAS REGISTRY NUMBER :
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1013-59-8
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LAST UPDATED :
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199506
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DATA ITEMS CITED :
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7
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MOLECULAR FORMULA :
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C10-H14-N-O3.Na
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MOLECULAR WEIGHT :
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219.24
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WISWESSER LINE NOTATION :
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T5MV EHJ CV1 DO EY2&1 &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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168 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - hemorrhage
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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146 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - hemorrhage
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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81 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - hemorrhage
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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115 mg/kg
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TOXIC EFFECTS :
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Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - hemorrhage
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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>40 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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90 mg/kg/9D-I
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TOXIC EFFECTS :
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Blood - hemorrhage
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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70 mg/kg/28D-I
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TOXIC EFFECTS :
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Gastrointestinal - necrotic changes Blood - hemorrhage Related to Chronic Data - death
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REFERENCE :
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CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO. Volume(issue)/page/year: 52,579,1968
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