870223-96-4
870223-96-4 structure
- Name: AMG-Tie2-1
- Chemical Name: 4-methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzamide
- CAS Number: 870223-96-4
- Molecular Formula: C25H20F3N5O2
- Molecular Weight: 479.454
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK VEGFR
- Create Date: 2018-12-25 10:58:16
- Modify Date: 2024-04-05 23:31:25
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AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively.
| Name | 4-methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzamide |
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| Synonyms |
4-methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)-N-(3-(trifluoromethyl)phenyl)benzamide
AMG-Tie2 4-Methyl-3-({3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide 4-methyl-3-({3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl}oxy)-N-[3-(trifluoromethyl)phenyl]benzamide pyridylpyrimidine ether 4 AMG-Tie2-1 Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]- |
| Description | AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC50 values of 1 and 3 nM, respectively. |
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| Related Catalog |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C25H20F3N5O2 |
| Molecular Weight | 479.454 |
| Exact Mass | 479.156921 |
| PSA | 95.75000 |
| LogP | 4.78 |
| Index of Refraction | 1.630 |