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Product Name: 4-HYDROXY-N-(4-METHOXY-7-MORPHOLINOBENZO[D]THIAZOL-2-YL)-4-METHYLPIPERIDINE-1-CARBOXAMIDE
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870070-55-6

870070-55-6 structure

870070-55-6 structure

Name: Tozadenant
Chemical Name: 4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-methylpiperidine-1-carboxamide
CAS Number: 870070-55-6
Molecular Formula: C₁₉H₂₆N₄O₄S
Molecular Weight: 406.499
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-12-24 15:36:35
Modify Date: 2026-07-12 21:26:49
Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.

Name	4-hydroxy-N-(4-methoxy-7-morpholin-4-yl-1,3-benzothiazol-2-yl)-4-methylpiperidine-1-carboxamide
Synonyms	Tozadenant, 10 mM in DMSO SYN-115 (Tozadenant) 4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-cboxamide SYN-115;SYN115;SYN 4-Hydroxy-N-(4-methoxy-7-morpholinobenzo(d)thiazol-2-yl)-4-methylpiperidine-1-carboxamide 1-Piperidinecboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl 4-Hydroxy-N-[4-methoxy-7 4-Methoxy-7-morpholino-2-[(4-hydroxy-4-methylpiperidino)cbonylamino]benzothiazole RO-4494351 4-hydroxy-n-(4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl)-4-methyl-1-piperidinecarboxamide RO4494351 4-hydroxy-4-methyl-piperidine-1-carboxylic acid(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide P1 rector,SYN-115,Adenosine Rector,SYN 115,Tozadenant,Inhibitor,inhibit SYN-115 Tozadenant (SYN-115) 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-1,3-benzothiazol-2-yl]-4-methyl-1-piperidinecarboxamide Tozadenant (USAN) 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecboxamide

Description	Tozadenant is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Neurological Disease
Target	Ki: 6 nM (Rhesus A2A), 11.5 nM (Human A2A)
In Vivo	18F-MNI-444 regional uptake is consistent with A2A receptor distribution in the brain. Selectivity is demonstrated by dose-dependent blocking by tozadenant (1.5, 10.5 mg/kg) and preladenant[1].
References	[1]. Olivier Barret, et al. Adenosine 2A Receptor Occupancy by Tozadenant and Preladenant in Rhesus Monkeys. J Nucl Med. 2014 Oct;55(10):1712-8.

Density	1.4±0.1 g/cm3
Molecular Formula	C₁₉H₂₆N₄O₄S
Molecular Weight	406.499
Exact Mass	406.167480
PSA	118.89000
LogP	0.43
Index of Refraction	1.662

HS Code	2934999090

383869-80-5 structure

383869-80-5

3970-68-1 structure

3970-68-1

~78%

870070-55-6 structure

870070-55-6

Literature: Flohr, Alexander; Moreau, Jean-Luc; Poli, Sonia Maria; Riemer, Claus; Steward, Lucinda Patent: US2005/261289 A1, 2005 ; Location in patent: Page/Page column 7 ; US 20050261289 A1

Precursor 2
383869-80-5 3970-68-1
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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