552309-42-9

552309-42-9 structure

Name: T16Ainh-A01
Chemical Name: 2-[(5-Ethyl-4-hydroxy-6-methyl-2-pyrimidinyl)sulfanyl]-N-[4-(4-me thoxyphenyl)-1,3-thiazol-2-yl]acetamide
CAS Number: 552309-42-9
Molecular Formula: C₁₉H₂₀N₄O₃S₂
Molecular Weight: 416.52
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2016-10-16 19:12:09
Modify Date: 2024-02-08 21:17:48
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[1][2].

Name	2-[(5-Ethyl-4-hydroxy-6-methyl-2-pyrimidinyl)sulfanyl]-N-[4-(4-me thoxyphenyl)-1,3-thiazol-2-yl]acetamide
Synonyms	T16Ainh-A01

Description	T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Others
Target	TMEM16A[1].
References	[1]. Fedigan S, et al. Effects of new-generation TMEM16A inhibitors on calcium-activated chloride currents in rabbit urethral interstitial cells of Cajal. Pflugers Arch. 2017 Nov;469(11):1443-1455. [2]. Namkung W, et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011 Jan 21;286(3):2365-74.

RIDADR	NONH for all modes of transport