467458-02-2

467458-02-2 structure

Name: Lu AE58054 (Hydrochloride)
Chemical Name: 2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine,hydrochloride
CAS Number: 467458-02-2
Molecular Formula: C₂₀H₂₀ClF₅N₂O
Molecular Weight: 434.831
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2017-02-09 16:54:58
Modify Date: 2024-01-31 07:24:33
Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.

Name	2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]ethanamine,hydrochloride
Synonyms	1H-Indole-3-ethanamine, 6-fluoro-N-[[3-(2,2,3,3-tetrafluoropropoxy)phenyl]methyl]-, hydrochloride (1:1) CS-1359 2-(6-Fluoro-1H-indol-3-yl)-N-[3-(2,2,3,3-tetrafluoropropoxy)benzyl]ethanamine hydrochloride (1:1) N-(2-(6-fluoro-1H-indol-3-yl)ethyl)-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride Lu AE58054 (Hydrochloride)

Description	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Arnt J, et al. Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. [2]. Witten L, et al. Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.

399-51-9

467458-02-2

Literature: H. LUNDBECK A/S Patent: US2011/152539 A1, 2011 ;

343-93-1

467458-02-2

Literature: H. LUNDBECK A/S Patent: US2011/152539 A1, 2011 ;

Precursor 2
399-51-9 343-93-1
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