23555-00-2

23555-00-2 structure

Name: HOECHST 34580
Chemical Name: N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
CAS Number: 23555-00-2
Molecular Formula: C₂₇H₂₉N₇
Molecular Weight: 451.57
Catalog: Dye Reagents
Create Date: 2017-03-20 03:40:46
Modify Date: 2024-01-08 17:50:11
Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.

Name	N,N-dimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
Synonyms	2'-(4-DIMETHYLAMINOPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE CS-1303 N,N-dimethyl-4-[5-(4-methyl-piperazin-1-yl)-1(3)H,1'(3')H-[2,5']bibenzoimidazolyl-2'-yl]-aniline BBZ 4-dimethylamino-1-{5'-[5''-(4'''-methylpiperazin-1'''-yl)-1H-benzimidazol-2''-yl]-3H-benzimidazol-2'-yl}benzene Proamine para-dimethylamino-Hoechst HOECHST 34580

Description	Hoechst 34580 is a cell-permeable fluorescent dye for staining DNA and nuclei.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Amyloid-β Dye Reagents Research Areas >> Neurological Disease
Target	Amyloid-β[1]
In Vitro	Hoechst 34580 prefers to locate near hydrophobic regions with binding affinity with the inhibition constant IC50 of 0.86±0.05 μM for Hoechst 34580. Hoechst 34580 is a good candidate for treating the Alzheimer’s disease by inhibiting Aβ formation. 50 μM Aβ42 solutions co-incubated with 100, 25, 12.5, 3.125, 0.78, and 0.1, 0.01 μM Hoechst 34580 at 37 °C for 70 h. Hoechst 34580 can inhibit the aggregation of Aβ42 in a dose-dependent manner. And the half-maximal concentration (IC50) is examined. The IC50 is obtained by measuring the concentration of Hoechst 34580 while maintaining the Aβ42 concentration which gave 0.86±0.05 μM for Hoechst 34580[1].
References	[1]. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50.