202914-84-9

202914-84-9 structure

Name: Lomitapide Mesylate
Chemical Name: lomitapide mesylate
CAS Number: 202914-84-9
Molecular Formula: C₄₀H₄₁F₆N₃O₅S
Molecular Weight: 789.82600
Catalog: Research Areas Cardiovascular Disease
Create Date: 2016-12-15 20:07:50
Modify Date: 2024-01-04 11:58:38
Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.IC50 value: 8 nM [1]Target: MTP inhibitorLomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.

Name	lomitapide mesylate
Synonyms	methanesulfonic acid,N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide UNII-X4S83CP54E AEGR-733 Lomitapide mesylate Juxtapid Lomitapide (mesylate)

Description	Lomitapide mesylate(AEGR-733; BMS-201038) is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.IC50 value: 8 nM [1]Target: MTP inhibitorLomitapide is a small-molecule, microsomal triglyceride transfer protein (MTP) inhibitor, for the treatment of both familial and primary hypercholesterolemia. Oral, once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors (statins) either due to abnormalities in liver function or to discontinuation because of muscle pain.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
References	[1]. Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70. [2]. Lomitapide. Am J Cardiovasc Drugs. 2011 Oct 1;11(5):347-52. [3]. Perry CM. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia. Am J Cardiovasc Drugs. 2013 Aug;13(4):285-96.