144604-00-2
144604-00-2 structure
- Name: 2-Hydroxysuccinic acid-(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4- methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl a cetate (1:1)
- Chemical Name: 2-Hydroxysuccinic acid-(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4- methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl a cetate (1:1)
- CAS Number: 144604-00-2
- Molecular Formula: C26H32N2O9S
- Molecular Weight: 548.60500
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
- Create Date: 2018-06-12 18:49:51
- Modify Date: 2025-09-19 01:10:56
-
Diltiazem malate is a potent and orally active L-type calcium chanel inhibitor. Diltiazem malate shows antihypertensive and antiarrhythmic effects. Diltiazem malate can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3].
| Name | 2-Hydroxysuccinic acid-(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4- methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl a cetate (1:1) |
|---|
| Description | Diltiazem malate is a potent and orally active L-type calcium chanel inhibitor. Diltiazem malate shows antihypertensive and antiarrhythmic effects. Diltiazem malate can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Diltiazem malate (200 µM) elicits a use-dependent blockade that proceeded within a relatively small number of pulses[1].Diltiazem malate reduces Ca2+ influx by accelerating inactivation during action potentials, and that the use-dependent blockade is due to increases in the number of channels in a sustained closed state[1]. |
| In Vivo | Diltiazem malate (100 mg/kg; p.o.; daily for 4 weeks) prevents aortic aneurysm formation in a blood pressure-independent manner[3].Diltiazem malate (100 mg/kg; p.o.; daily for 6 days) with ATII (1.44 mg/kg; p.o.; daily for 6 days) reduces the ATII-induced vascular inflammation and macrophage accumulation in ApoE−/− mice[3].Diltiazem malate (2 mg/kg; i.v.) exhibits T1/2 of 61.2 min, CLel of 3.2 mL/min in rats[4]. |
| References |
| Boiling Point | 594.4ºC at 760 mmHg |
|---|---|
| Molecular Formula | C26H32N2O9S |
| Molecular Weight | 548.60500 |
| Flash Point | 313.3ºC |
| Exact Mass | 548.18300 |
| PSA | 179.21000 |
| LogP | 2.34010 |
| Vapour Pressure | 4.27E-14mmHg at 25°C |