10448-84-7
10448-84-7 structure
- Name: Nitromifene
- Chemical Name: 1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine
- CAS Number: 10448-84-7
- Molecular Formula: C27H28N2O4
- Molecular Weight: 444.52200
- Catalog: Research Areas Cancer
- Create Date: 2018-04-14 08:00:00
- Modify Date: 2024-01-12 09:15:48
-
Nitromifene is an antagonist of estrogen receptor (ER).
| Name | 1-[2-[4-[(Z)-1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]pyrrolidine |
|---|---|
| Synonyms |
Nitromifeno [INN-Spanish]
CN-55,945 1-(4-<2-(1-pyrrolidinyl)ethoxy>phenyl)-1-(4-methoxyphenyl)-2-nitro-2-phenylethylene 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-pyrrolidine Nitromifenum [INN-Latin] NITROMIFENE Pyrrolidine,1-(2-(4-(1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl)phenoxy)ethyl) nitromiphene Nitromifeno |
| Description | Nitromifene is an antagonist of estrogen receptor (ER). |
|---|---|
| Related Catalog | |
| Target |
ER[1] |
| In Vitro | Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1]. |
| Cell Assay | MCF 7 cells are used in this study. The experiment is carried out in 6-well cluster plates. To each well is added 5 mL of a suspension of 2×105 cells in log phase growth. Medium is changed after 48 h and after 96 h, medium is replaced with 5 mL of serum-free medium containing 2 nM of the radioligand. Nitromifene is dissolved in DMSO (5 μL) to give final concentrations of 0, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM. Nonspecific binding is determined in incubations to which the radioinert counterpart of the radioligand is added at a concentration of 1 μM. Incubations are run in triplicate for 1 h at 37°C. |
| References |
| Density | 1.183g/cm3 |
|---|---|
| Boiling Point | 576.7ºC at 760mmHg |
| Molecular Formula | C27H28N2O4 |
| Molecular Weight | 444.52200 |
| Flash Point | 302.6ºC |
| Exact Mass | 444.20500 |
| PSA | 67.52000 |
| LogP | 5.82420 |
| Vapour Pressure | 2.66E-13mmHg at 25°C |
| Index of Refraction | 1.605 |
| Storage condition | 2-8℃ |
| HS Code | 2933990090 |
|---|
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |