103898-38-0

103898-38-0 structure

Name: SM-6586
Chemical Name: methyl (5E)-5-[3-[[benzyl(methyl)amino]methyl]-2H-1,2,4-oxadiazol-5-ylidene]-2,6-dimethyl-4-(3-nitrophenyl)-4H-pyridine-3-carboxylate
CAS Number: 103898-38-0
Molecular Formula: C₂₆H₂₇N₅O₅
Molecular Weight: 489.52300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2016-12-14 19:37:57
Modify Date: 2024-01-12 19:03:40
SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

Name	methyl (5E)-5-[3-[[benzyl(methyl)amino]methyl]-2H-1,2,4-oxadiazol-5-ylidene]-2,6-dimethyl-4-(3-nitrophenyl)-4H-pyridine-3-carboxylate
Synonyms	SM-6586

Description	SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> Na+/Ca2+ Exchanger Research Areas >> Cardiovascular Disease
In Vivo	In SM-6586-treated spontaneously hypertensive rats, the survival rate after bilateral common carotid artery ligation is higher, the brain water content is lower, and the ATP level is higher and lactate level. In focal ischemia models, the SM-treated group shows a reduction of T1 relaxation time. The brain water content is significantly decreased in the SM-treated group[1].
References	[1]. Kashiwagi F, et al. Effect of a new calcium antagonist (SM-6586) on experimental cerebral ischemia. Acta Neurochir Suppl (Wien). 1994;60:289-92.