1311385-32-6

1311385-32-6 structure

Name: LY2979165
Chemical Name: (1R,2R,4S,5R,6R)-4-[[(2S)-2-aminopropanoyl]amino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-4,6-dicarboxylic acid, azane, hydrate
CAS Number: 1311385-32-6
Molecular Formula: C₁₃H₂₂N₆O₆S
Molecular Weight: 390.415
Catalog: Research Areas Neurological Disease
Create Date: 2017-04-04 23:52:04
Modify Date: 2025-08-22 19:57:10
LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.IC50 Value:Target: mGluR

Name	(1R,2R,4S,5R,6R)-4-[[(2S)-2-aminopropanoyl]amino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-4,6-dicarboxylic acid, azane, hydrate
Synonyms	CS-0457 Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-[[(2S)-2-amino-1-oxopropyl]amino]-4-(4H-1,2,4-triazol-3-ylthio)-, ammonium salt, (1R,2S,4R,5R,6R)-, hydrate (1:1) mGlu2 agonist (1R,2S,4R,5R,6R)-2-(L-Alanylamino)-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic acid ammoniate hydrate LY2979165

Description	LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.IC50 Value:Target: mGluR
Related Catalog	Research Areas >> Neurological Disease
References	[1]. http://clinicaltrials.gov/ct2/show/NCT01383967 [2]. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15. [3]. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 recepto [4]. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54. [5]. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate