32162-64-4
32162-64-4 structure
- Name: R-(+)-Cotinine
- Chemical Name: (-)-cotinine
- CAS Number: 32162-64-4
- Molecular Formula: C10H12N2O
- Molecular Weight: 176.22
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-06-27 16:19:47
- Modify Date: 2025-09-11 00:16:18
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R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].
| Name | (-)-cotinine |
|---|---|
| Synonyms |
COTININE (+)-
R-(+)-Cotinine R-(+)-COTININE ((5R)-(+)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE) |
| Description | R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1]. |
|---|---|
| Related Catalog | |
| In Vitro | R-(+)-Cotinine (1 μM) significantly enhances the Ach (40 μM)-evoked current in human α7 nAChRs[1]. |
| In Vivo | R-(+)-Cotinine (0.3-10 mg/kg; a single i.p.) enhances the effects of a subthreshold dose of Donepezil (0.5 mg/kg) on novel object recognition (NOR) performance[1]. |
| References |
| Molecular Formula | C10H12N2O |
|---|---|
| Molecular Weight | 176.22 |
| Exact Mass | 176.09500 |
| PSA | 33.20000 |
| LogP | 1.31280 |
| HS Code | 2933990090 |
|---|
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |