Shanghai Nianxing Industrial Co., Ltd
China
Product Name: R-(+)-Cotinine
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: R-(+)-Cotinine
Price: $Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao

32162-64-4

32162-64-4 structure

32162-64-4 structure

Name: R-(+)-Cotinine
Chemical Name: (-)-cotinine
CAS Number: 32162-64-4
Molecular Formula: C₁₀H₁₂N₂O
Molecular Weight: 176.22
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-27 16:19:47
Modify Date: 2024-01-16 11:43:30
R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].

Name	(-)-cotinine
Synonyms	COTININE (+)- R-(+)-Cotinine R-(+)-COTININE ((5R)-(+)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE)

Description	R-(+)-Cotinine ((+)-Cotinine), a Nicotine metabolite, lacks significant activity across a wide range of pharmacological targets. R-(+)-Cotinine can enhance the Ach-evoked current in human α7 nAChRs[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	R-(+)-Cotinine (1 μM) significantly enhances the Ach (40 μM)-evoked current in human α7 nAChRs[1].
In Vivo	R-(+)-Cotinine (0.3-10 mg/kg; a single i.p.) enhances the effects of a subthreshold dose of Donepezil (0.5 mg/kg) on novel object recognition (NOR) performance[1].
References	[1]. Jr AVT, et, al. R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo. J Pharmacol Exp Ther. 2015 Feb;352(2):405-18.

Molecular Formula	C₁₀H₁₂N₂O
Molecular Weight	176.22
Exact Mass	176.09500
PSA	33.20000
LogP	1.31280

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%