170858-33-0

170858-33-0 structure

Name: Sonepiprazole
Chemical Name: Sonepiprazole hydrate
CAS Number: 170858-33-0
Molecular Formula: C₂₁H₂₇N₃O₃S
Molecular Weight: 401.52200
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2016-06-25 16:48:37
Modify Date: 2024-01-05 23:04:44
Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively[1].

Name	Sonepiprazole hydrate
Synonyms	Sonepiprazole Ritanserin Benzenesulfonamide

Description	Sonepiprazole (PNU-101387G) is a selective D4 dopamine antagonist with Kis of 3.6, 10.1, 5147, and 7430 nM for rD4-Dopamine, hD4.2-Dopamine, rD2-Dopamine, and Histamine-H1 receptors, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	rD4 Receptor:3.6 nM (Ki) hD4 Receptor:10.1 nM (Ki) rD2 Receptor:5147 nM (Ki) Histamine H1 Receptor:7430 nM (Ki)
In Vitro	Sonepiprazole exhibits highly specific binding to the D4 dopamine receptor with more than 100-fold selectivity for the D4 receptor over other receptors, including dopamine, serotonin, and adrenergic receptors[1].
References	[1]. Mark H Corrigan, et al. Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial. Biol Psychiatry. 2004 Mar 1;55(5):445-51.