129273-38-7
129273-38-7 structure
- Name: Perospirone hydrochloride
- Chemical Name: Perospirone Hydrochloride Trihydrate
- CAS Number: 129273-38-7
- Molecular Formula: C23H31ClN4O2S
- Molecular Weight: 463.036
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-08-21 08:18:40
- Modify Date: 2024-01-02 18:31:53
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Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].
| Name | Perospirone Hydrochloride Trihydrate |
|---|---|
| Synonyms |
MFCD08457543
Perospirone hydrochloride (3aR,7aS)-2-{4-[4-(1,2-Benzothiazol-3-yl)-1-piperazinyl]butyl}hexahydro-1H-isoindole-1,3(2H)-dione hydrochloride (1:1) 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-, hydrochloride (1:1) |
| Description | Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2]. |
|---|---|
| Related Catalog | |
| Target |
5-HT2A Receptor:0.6 nM (Ki) D2 Receptor:1.4 nM (Ki) 5-HT1A Receptor:2.9 nM (Ki) 5-HT1 Receptor:18 nM (Ki) D1 Receptor:41 nM (Ki) |
| References |
| Boiling Point | 667.4ºC at 760 mmHg |
|---|---|
| Melting Point | 95-970ºC |
| Molecular Formula | C23H31ClN4O2S |
| Molecular Weight | 463.036 |
| Flash Point | 357.4ºC |
| Exact Mass | 462.185638 |
| PSA | 84.99000 |
| LogP | 4.11650 |
| Storage condition | -20°C Freezer |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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