434938-41-7

434938-41-7 structure

Name: K41498
Chemical Name: k 41498
CAS Number: 434938-41-7
Molecular Formula: C₁₆₂H₂₇₆N₄₈O₄₆
Molecular Weight: 3632.22000
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2016-01-14 08:25:15
Modify Date: 2025-08-27 17:50:13
K41498 is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively hypotension. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 can be used for hypotension study[1].

Name	k 41498

Description	K41498 is a potent and highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively hypotension. K41498 is an analogues of antisauvagine-30 (aSvg-30), inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. K41498 can be used for hypotension study[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> CRFR
References	[1]. A Rühmann, et al. Design, synthesis and pharmacological characterization of new highly selective CRF(2) antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides. 2002 Mar;23(3):453-60. [2]. A J Lawrence, et al. The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain. Br J Pharmacol