Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Motilin (26-47), human, porcine
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Purity: 98.0%
Stocking Period: 10 Day
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52906-92-0

52906-92-0 structure

52906-92-0 structure

Name: Motilin (26-47), human, porcine
Chemical Name: Motilin porcine
CAS Number: 52906-92-0
Molecular Formula: C₁₂₀H₁₈₈N₃₄O₃₅S
Molecular Weight: 2699.05000
Catalog: Peptides
Create Date: 2018-07-22 14:17:38
Modify Date: 2024-01-05 04:39:11
Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.

Name	Motilin porcine
Synonyms	Motilin (26-47), human, porcine

Description	Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Motilin Receptor Research Areas >> Others Peptides
Target	EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)[1] Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)[1]
In Vitro	[Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2].
References	[1]. Coulie B, et al. Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling. J Biol Chem. 2001 Sep 21;276(38):35518-22. Epub 2001 Jul 18. [2]. Huang J, et al. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31.

Molecular Formula	C₁₂₀H₁₈₈N₃₄O₃₅S
Molecular Weight	2699.05000
Exact Mass	2697.37000
PSA	1191.49000
LogP	4.75460

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

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