52906-92-0
52906-92-0 structure
- Name: Motilin (26-47), human, porcine
- Chemical Name: Motilin porcine
- CAS Number: 52906-92-0
- Molecular Formula: C120H188N34O35S
- Molecular Weight: 2699.05000
- Catalog: Peptides
- Create Date: 2018-07-22 14:17:38
- Modify Date: 2024-01-05 04:39:11
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Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line.
| Name | Motilin porcine |
|---|---|
| Synonyms | Motilin (26-47), human, porcine |
| Description | Motilin(human, porcine) is an endogenous motilin receptor ligand with Ki and EC50 of 2.3 nM and 0.3 nM in a Chinese hamster ovary cell line. |
|---|---|
| Related Catalog | |
| Target |
EC50: 0.3 nM (motilin receptor, Chinese hamster ovary cell)[1] Ki: 2.3 nM (motilin receptor, Chinese hamster ovary cell)[1] |
| In Vitro | [Bpa1,Ile13]motilin is a full agonist at the motilin receptor that increases intracellular calcium in a concentration-dependent manner (EC50 = 1.5 ± 0.4 nM)[1]. Motilin binds with high affinity (IC50 0.7± 0.2 nM) to receptors on smooth muscle cells. Motilin selectively activates G(q) and G(13), stimulates G alpha(q)-dependent phosphoinositide (PI) hydrolysis and 1,4,5-trisphosphate (IP(3))-dependent Ca2+ release, and increases cytosolic free Ca2+. Motilin induces a biphasic, concentration-dependent contraction (EC50 = 1.0 +/- 0.2 nM), consisting of an initial peak followed by a sustained contraction[2]. |
| References |
| Molecular Formula | C120H188N34O35S |
|---|---|
| Molecular Weight | 2699.05000 |
| Exact Mass | 2697.37000 |
| PSA | 1191.49000 |
| LogP | 4.75460 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |