- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Methyl 1-Cbz-azetidine-3-carboxylate
- Price: ￥648.0/1g ￥268.0/250mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: Methyl 1-Cbz-azetidine-3-carboxylate
- Price: ￥Inquiry/10g
- Purity: 98.0%
- Stocking Period: 14 Day
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: Methyl 1-Cbz-azetidine-3-carboxylate
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
757239-60-4
757239-60-4 structure
- Name: Methyl 1-Cbz-azetidine-3-carboxylate
- Chemical Name: 1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate
- CAS Number: 757239-60-4
- Molecular Formula: C13H15NO4
- Molecular Weight: 249.262
- Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
- Create Date: 2018-12-31 15:43:35
- Modify Date: 2024-01-02 19:01:47
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Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
| Name | 1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate |
|---|---|
| Synonyms |
1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER
1-[(Benzyloxy)carbonyl]-3-methyl-3-azetidinecarboxylic acid 1-Cbz-3-azetidinecarboxylic acid methyl ester 1-Benzyl 3-methyl 1,3-azetidinedicarboxylate Methyl1-Cbz-azetidine-3-carboxylate 1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE HT799 Azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 1,3-Azetidinedicarboxylic acid, 3-methyl-, 1-(phenylmethyl) ester methyl 1-benzyloxycarbonyl-3-azetidinecarboxylate |
| Description | Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1 |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 414.9±45.0 °C at 760 mmHg |
| Molecular Formula | C13H15NO4 |
| Molecular Weight | 249.262 |
| Flash Point | 204.7±28.7 °C |
| Exact Mass | 249.100113 |
| PSA | 55.84000 |
| LogP | 1.42 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.580 |
| HS Code | 2933990090 |
|---|
|
~10%
757239-60-4 |
| Literature: Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L. Patent: US2006/229289 A1, 2006 ; Location in patent: Page/Page column 19 ; |
|
~%
757239-60-4 |
| Literature: US2011/183960 A1, ; Page/Page column 27 ; |
|
~98%
757239-60-4 |
| Literature: MERCK SHARP and DOHME LIMITED Patent: WO2004/78750 A1, 2004 ; Location in patent: Page 81 ; WO 2004/078750 A1 |
| Precursor 5 | |
|---|---|
| DownStream 2 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |