Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE
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Purity: 98.0%
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757239-60-4

757239-60-4 structure

Name: Methyl 1-Cbz-azetidine-3-carboxylate
Chemical Name: 1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate
CAS Number: 757239-60-4
Molecular Formula: C₁₃H₁₅NO₄
Molecular Weight: 249.262
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-12-31 15:43:35
Modify Date: 2026-07-01 17:51:12
Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

Name	1-O-benzyl 3-O-methyl azetidine-1,3-dicarboxylate
Synonyms	1-Cbz-3-azetidinecboxylic acid Methyl ester 1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER 1-Cbz-3-azetidinecarboxylic acid methyl ester 1-Benzyl 3-methyl 1,3-azetidinedicarboxylate 1-CBZ-AZETIDINE-3-CBOXYLIC ACID METHYL ESTER 1-BENZYL 3-METHYL AZETIDINE-1,3-DICARBOXYLATE azetidine-1,3-dicboxylic acid O3-methyl ester O1-(phenylmethyl) ester O1-benzyl O3-methyl azetidine-1,3-dicboxylate 1,3-Azetidinedicarboxylic acid, 3-methyl-, 1-(phenylmethyl) ester 1-benzyloxycbonyl-3-azetidinecboxylic acid methyl ester Methyl 1-Cbz-azetidine-3 Methyl 1-benzyloxycbonylazetidine-3-cboxylate 1-[(Benzyloxy)carbonyl]-3-methyl-3-azetidinecarboxylic acid Methyl1-Cbz-azetidine-3-carboxylate HT799 1-benzyl 3-Methyl azetidine-1,3-dicboxylate Azetidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester Methyl 1-Cbz-azetidine-3-cboxylate methyl 1-benzyloxycarbonyl-3-azetidinecarboxylate

Description	Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	414.9±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₅NO₄
Molecular Weight	249.262
Flash Point	204.7±28.7 °C
Exact Mass	249.100113
PSA	55.84000
LogP	1.42
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.580

HS Code	2933990090

186581-53-3

97628-92-7

~10%

757239-60-4

Literature: Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Virajkumar B.; Penning, Thomas D.; Giranda, Vincent L. Patent: US2006/229289 A1, 2006 ; Location in patent: Page/Page column 19 ;

100202-39-9

501-53-1

757239-60-4

Literature: US2011/183960 A1, ; Page/Page column 27 ;

97628-92-7

18107-18-1

~98%

757239-60-4

Literature: MERCK SHARP and DOHME LIMITED Patent: WO2004/78750 A1, 2004 ; Location in patent: Page 81 ; WO 2004/078750 A1

Precursor 5
97628-92-7 18107-18-1 186581-53-3 100202-39-9
501-53-1
DownStream 2
97628-92-7 912444-78-1

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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