71439-68-4

71439-68-4 structure

Name: CL-216942
Chemical Name: 9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], dihydrochloride
CAS Number: 71439-68-4
Molecular Formula: C₂₂H₂₃ClN₈
Molecular Weight: 434.92500
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2018-07-04 17:53:41
Modify Date: 2024-01-13 13:26:18
Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].

Name	9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone], dihydrochloride
Synonyms	9,10-anthracenedicarboxaldehyde bis<(4,5-dihydro-1H-imidazol-2-yl)hydrazone> dihydrochloride Bisantrene hydrochloride Bisantrene dihydrochloride 9,10-Anthracenedicarboxaldehyde bis(2-imidazolin-2-ylhydrazone) dihydrochloride

Description	Bisantrene dihydrochloride is a highly effective antitumor agent, it exerts its cytotoxicity by affecting DNA intercalation. Bisantrene dihydrochloride targets eukaryotic type II topoisomerases. Bisantrene dihydrochloride is a substrate of MDR1[1][2][3][4].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase[1]
In Vitro	Bisantrene dihydrochloride promots DNase I cleavage at oligopurine-oligopyrimidine tracts and slightly reduces the cleavage activity at alternating purine-pyrimidine sequences[1]. Bisantrene dihydrochloride is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA[2].
In Vivo	Bisantrene dihydrochloride is an antitumor agent active against a number of experimental tumors, including P388 leukemia, L1210 leukemia, Lieberman plasma cell tumor, B16 melanoma, colon tumor 26, and Ridgway osteogenic sarcoma[3]. Bisantrene dihydrochloride is effective over a dose range of 1.56 to 150 mg/kg depending upon the frequency, route, and schedule of the treatment and the tumor model used[3]. Bisantrene dihydrochloride (25, 50 and 100 mg/kg; i.p.; once) pretreats with macrophages shows antitumor effect to mice with P815 tumor cells injection[3]. Bisantrene dihydrochloride (10-150 mg/kg; i.v.; once) dose-dependently induces leukopenia in Neo mice. B cells and macrophages are targets for bisantrene dihydrochloride toxicity[4].

CHEMICAL NAME :: 9,10-Anthracenedicarboxaldehyde, bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone), dihydrochloride

WISWESSER LINE NOTATION :: L C666J B1UNM- BT5M CN BUTJ& I1UNM- BT5M CN BUTJ &GH 2

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 42,440,1982