58525-82-9

58525-82-9 structure

Name: l-azatyrosine
Chemical Name: l-azatyrosine
CAS Number: 58525-82-9
Molecular Formula: C₈H₁₀N₂O₃
Molecular Weight: 182.17700
Catalog: Research Areas Infection
Create Date: 2016-05-22 04:00:47
Modify Date: 2024-01-03 00:02:40
L-Azatyrosine is an antitumor antibiotic isolated from Streptomyces chibaensis. L-Azatyrosine can restore normal phenotypic behavior to transformed cells bearing oncogenic Ras genes[1][2].

Name	l-azatyrosine
Synonyms	4-Nitro-3-phenyl-L-alanine Phenylalanine,4-nitro L-p-Nitrophenylalanine L-4-Nitrophenylalanine 2-aza-L-tyrosine p-Nitro-L-phenylalanine L-Phenylalanine,4-nitro

Description	L-Azatyrosine is an antitumor antibiotic isolated from Streptomyces chibaensis. L-Azatyrosine can restore normal phenotypic behavior to transformed cells bearing oncogenic Ras genes[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
References	[1]. Adamczyk M, et, al. Enantioselective synthesis of (2-pyridyl)alanines via catalytic hydrogenation and application to the synthesis of L-azatyrosine. Org Lett. 2001 Oct 4;3(20):3157-9. [2]. Shindo-Okada N, et, al. Permanent conversion of mouse and human cells transformed by activated ras or raf genes to apparently normal cells by treatment with the antibiotic azatyrosine. Mol Carcinog. 1989;2(3):159-67.