59989-18-3

59989-18-3 structure

Name: Eniluracil
Chemical Name: 5-ethynyl-1H-pyrimidine-2,4-dione
CAS Number: 59989-18-3
Molecular Formula: C₆H₄N₂O₂
Molecular Weight: 136.10800
Catalog: Research Areas Cancer
Create Date: 2018-12-25 23:09:55
Modify Date: 2024-01-02 11:24:22
Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity[1].

Name	5-ethynyl-1H-pyrimidine-2,4-dione
Synonyms	ethynyluracil 5-ETHYNYLURACIL Compound 776C Eniluracil ethynyluracyl GW776C85 776C85

Description	Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	Dihydropyrimidine dehydrogenase[1]
References	[1]. Schilsky RL, et al. Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase. Expert Opin Investig Drugs. 2000 Jul;9(7):1635-49.

83355-90-2

~97%

59989-18-3

83355-88-8

~72%

59989-18-3

Literature: Kundu, Nitya G.; Das, Biswajit; Majumdar, Anjali Synthesis, 1990 , # 3 p. 243 - 245

83355-89-9

59989-18-3

Literature: Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 463 - 464

61751-45-9

59989-18-3

Literature: Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 463 - 464