59989-18-3
59989-18-3 structure
- Name: Eniluracil
- Chemical Name: 5-ethynyl-1H-pyrimidine-2,4-dione
- CAS Number: 59989-18-3
- Molecular Formula: C6H4N2O2
- Molecular Weight: 136.10800
- Catalog: Research Areas Cancer
- Create Date: 2018-12-25 23:09:55
- Modify Date: 2025-08-24 21:53:54
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Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity[1].
| Name | 5-ethynyl-1H-pyrimidine-2,4-dione |
|---|---|
| Synonyms |
ethynyluracil
5-ETHYNYLURACIL Compound 776C Eniluracil ethynyluracyl GW776C85 776C85 |
| Description | Eniluracil (5-Ethynyluracil), a uracil analogue and a mechanism-based irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD), increases the oral bioavailability of 5-fluorouracil (5-FU) to 100%, facilitating uniform absorption and predictable toxicity[1]. |
|---|---|
| Related Catalog | |
| Target |
Dihydropyrimidine dehydrogenase[1] |
| References |
| Density | 1.39g/cm3 |
|---|---|
| Melting Point | 320 °C(dec.) |
| Molecular Formula | C6H4N2O2 |
| Molecular Weight | 136.10800 |
| Exact Mass | 136.02700 |
| PSA | 65.72000 |
| Index of Refraction | 1.589 |
|
~97%
59989-18-3 |
| Literature: Cooke, Jason W. B.; Bright, Robert; Coleman, Mark J.; Jenkins, Kevin P. Organic Process Research and Development, 2001 , vol. 5, # 4 p. 383 - 386 |
|
~72%
59989-18-3 |
| Literature: Kundu, Nitya G.; Das, Biswajit; Majumdar, Anjali Synthesis, 1990 , # 3 p. 243 - 245 |
|
~%
59989-18-3 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 463 - 464 |
|
~%
59989-18-3 |
| Literature: Journal of Heterocyclic Chemistry, , vol. 19, # 3 p. 463 - 464 |
| Precursor 4 | |
|---|---|
| DownStream 2 | |
![FURO[2,3-D]PYRIMIDIN-2(3H)-ONE structure](https://image.chemsrc.com/caspic/457/62785-91-5.png)