1262406-02-9

1262406-02-9 structure

Name: JNK-1-IN-1
Chemical Name: N-Propyl-N-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,3-benzo thiazol-2-amine
CAS Number: 1262406-02-9
Molecular Formula: C₂₄H₂₂N₆S
Molecular Weight: 426.53700
Catalog: Signaling Pathways MAPK/ERK Pathway JNK
Create Date: 2016-01-04 13:48:51
Modify Date: 2024-01-13 13:34:15
JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1].

Name	N-Propyl-N-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1,3-benzo thiazol-2-amine

Description	JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> JNK
Target	JNK1
In Vitro	JNK-1-IN-1 (Compound 2) 对 HepG2 人肝癌细胞中的 Jnk1-u、p38α-u、ERK2-u 具有亲和力，Kd 值分别为 11、18、18[1]。 JNK-1-IN-1 抑制 HepG2 人肝癌细胞中的 MKK7cp，IC50 值为 7.8[1]。
References	[1]. Comess KM, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.