1061747-72-5

1061747-72-5 structure

Name: TC-G 1004
Chemical Name: N-{2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl )-2-pyridinyl]-4-pyrimidinyl}acetamide
CAS Number: 1061747-72-5
Molecular Formula: C₂₂H₂₇N₇O₂
Molecular Weight: 421.49500
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-12-18 16:55:10
Modify Date: 2024-01-09 22:53:24
TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively[1].

Name	N-{2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl )-2-pyridinyl]-4-pyrimidinyl}acetamide
Synonyms	cs-1344

Description	TC-G 1004 (compound 16j) is an orally active A2A adenosine receptor antagonist, with Ki values of 0.44 nM and 80 nM for hA2A and hA1, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Ki: 0.44 nM (hA2A), 80 nM (hA1)[1].
In Vitro	TC-G 1004 (compound 16j) is a highly potent A2A antagonist at both the human and rat receptors with greater than 100× selectivity over hA1[1].
In Vivo	TC-G 1004 (compound 16j, 3 mg/kg) displays good in vivo oral activity in rat models for Parkinson’s disease and were advanced to preclinical development[1]. TC-G 1004 (compound 16j) dose-dependently potentiates L-dopa induced rotations with an MED of 3 mg/kg when dosed orally[1].
References	[1]. Xiaohu Zhang, et al. Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease. J Med Chem. 2008 Nov 27;51(22):7099-110.

Molecular Formula	C₂₂H₂₇N₇O₂
Molecular Weight	421.49500
Exact Mass	421.22300
PSA	101.55000
LogP	3.62920

1061747-75-8

108-24-7

64-19-7

~41%

1061747-72-5

Literature: NEUROCRINE BIOSCIENCES, INC. Patent: WO2008/116185 A2, 2008 ; Location in patent: Page/Page column 44-45 ; WO 2008/116185 A2

1061750-08-0

4045-25-4

~22%

1061747-72-5

Literature: Zhang, Xiaohu; Tellew, John E.; Luo, Zhiyong; Moorjani, Manisha; Lin, Emily; Lanier, Marion C.; Chen, Yongsheng; Williams, John P.; Saunders, John; Lechner, Sandra M.; Markison, Stacy; Joswig, Tanya; Petroski, Robert; Piercey, Jaime; Kargo, William; Malany, Siobhan; Santos, Mark; Gross, Raymond S.; Wen, Jenny; Jalali, Kayvon; O'Brien, Zhihong; Stotz, Carol E.; Crespo, Maria I.; Diaz, Jose-Luis; Slee, Deborah H. Journal of Medicinal Chemistry, 2008 , vol. 51, # 22 p. 7099 - 7110

Precursor 5
1061747-75-8 108-24-7 64-19-7 1061750-08-0
4045-25-4
DownStream 0

1061747-72-5	1621175-65-2
1021912-42-4	1415407-60-1
245744-18-7	1324003-64-6
494191-73-0	1257256-44-2
770-71-8	867017-68-3