63638-91-5
63638-91-5 structure
- Name: Brofaromine
- Chemical Name: 4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine
- CAS Number: 63638-91-5
- Molecular Formula: C14H16BrNO2
- Molecular Weight: 310.18600
- Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
- Create Date: 2017-12-09 17:24:00
- Modify Date: 2024-01-14 20:33:01
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Brofaromine is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 μM for MAO-A.
| Name | 4-(7-Bromo-5-methoxy-1-benzofuran-2-yl)piperidine |
|---|---|
| Synonyms |
Brodimoprimum
Brofaromine Hyprim Bromdimoprim Brodimoprima Brodimoprime brodimoprim |
| Description | Brofaromine is a monoamine oxidase (MAO) inhibitor with IC50 of 0.2 μM for MAO-A. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.2 μM (MAO-A)[1] |
| In Vitro | In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine (BRO) is determined on the activity of MAO-A in cultured cortical cells. It shows, firstly, that cultured cortical cells have a significant MAO-A activity, and secondly, that Brofaromine inhibits the enzyme in a concentration-dependent manner. The IC50 is 0.19 μM for Brofaromine . Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10 μM . Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01 μM to 0.1 μM[1]. |
| References |
| Density | 1.386g/cm3 |
|---|---|
| Boiling Point | 404ºC at 760 mmHg |
| Molecular Formula | C14H16BrNO2 |
| Molecular Weight | 310.18600 |
| Flash Point | 198.2ºC |
| Exact Mass | 309.03600 |
| PSA | 34.40000 |
| LogP | 3.99970 |
| Index of Refraction | 1.588 |
| Storage condition | 2-8℃ |
| HS Code | 2934999090 |
|---|
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |