867365-76-2

867365-76-2 structure

Name: RO0335
Chemical Name: 2-[4-Bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]-N-(2-chlor o-4-sulfamoylphenyl)acetamide
CAS Number: 867365-76-2
Molecular Formula: C₂₁H₁₃BrCl₂FN₃O₄S
Molecular Weight: 573.21900
Catalog: Signaling Pathways Anti-infection Reverse Transcriptase
Create Date: 2017-01-03 02:32:53
Modify Date: 2024-01-19 20:14:07
RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].

Name	2-[4-Bromo-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]-N-(2-chlor o-4-sulfamoylphenyl)acetamide

Description	RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Anti-infection >> Reverse Transcriptase
References	[1]. Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86(2):212-219.