Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ethyl 2-(4-chlorophenyl)-5-ethoxy-4-oxazoleacetate
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Purity: 98.0%
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59399-41-6

59399-41-6 structure

59399-41-6 structure

Name: Y-9738
Chemical Name: Ethyl [2-(4-chlorophenyl)-5-ethoxy-1,3-oxazol-4-yl]acetate
CAS Number: 59399-41-6
Molecular Formula: C₁₅H₁₆ClNO₄
Molecular Weight: 309.74500
Catalog: Research Areas Cardiovascular Disease
Create Date: 2016-02-03 17:48:29
Modify Date: 2024-01-10 18:59:57
Y-9738 is a hypolipidemic agent.

Name	Ethyl [2-(4-chlorophenyl)-5-ethoxy-1,3-oxazol-4-yl]acetate
Synonyms	[2-(4-chlorophenyl)-3H-imidazol-4-yl]methanol ethyl-2-(4-chlorophenyl)-5-ethoxy-4-oxazole acetate [2-(4-chloro-phenyl)-5-ethoxy-oxazol-4-yl]-acetic acid ethyl ester ethyl 2-p-chlorophenyl-5-ethoxy-4-oxazoleacetate Y-9738

Description	Y-9738 is a hypolipidemic agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cardiovascular Disease
In Vivo	Y-9738 is a hypolipidemic agent. At 100 mg/kg Y-9738 lowers the cholesterol level by 36% and clearly diminishes the intensity of the β-lipoprotein band with a tendency for the α-lipoprotein band to be intensified. Y-9738 causes a dose-dependent decrease in serum cholesterol, triglyceride and heparin-precipitable β-lipoprotein cholesterol. Furthermore, Y-9738 reduces the intensity of the β-lipoprotein band shown by electrophoresis, and increases that of the α-lipoprotein band[1].
Animal Admin	Male Sprague-Dawley rats are used in this work. Rats (140 to 180 g) are fed a high cholesterol diet for 10 days. This diet contains 1% cholesterol, 0.2% sodium cholate and 5% olive oil. Y-9738 is orally administered to the animals once a day throughout the experimental period. All animals are starved overnight (about 20 h) after the last treatment and sacrificed by carotid incision. Blood and liver are collected for lipid analysis[1].
References	[1]. Kobayakawa T, et al. Experimental hyper-beta-lipoproteinemia and its amelioration by a novel hypolipidemic agent. Atherosclerosis. 1978 Jul;30(3):219-25.

Density	1.226g/cm3
Boiling Point	416.2ºC at 760 mmHg
Molecular Formula	C₁₅H₁₆ClNO₄
Molecular Weight	309.74500
Flash Point	205.5ºC
Exact Mass	309.07700
PSA	61.56000
LogP	3.49930
Index of Refraction	1.53
Storage condition	2-8℃

74-96-4 structure

74-96-4

59399-45-0 structure

59399-45-0

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59399-41-6 structure

59399-41-6

Literature: Yoshitomi Pharmaceutical Industries, Ltd. Patent: US4012412 A1, 1977 ;