69956-77-0

69956-77-0 structure

Name: Pelubiprofen
Chemical Name: 2-[4-[(E)-(2-oxocyclohexylidene)methyl]phenyl]propanoic acid
CAS Number: 69956-77-0
Molecular Formula: C₁₆H₁₈O₃
Molecular Weight: 258.312
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-06-18 19:26:21
Modify Date: 2024-01-09 19:46:46
Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].

Name	2-[4-[(E)-(2-oxocyclohexylidene)methyl]phenyl]propanoic acid
Synonyms	2-[4-(2-oxo-1-cyclohexyliden methyl)-phenyl]propionic acid Benzeneacetic acid, α-methyl-4-[(E)-(2-oxocyclohexylidene)methyl]- 2-Ocmpp 2-{4-[(E)-(2-Oxocyclohexylidene)methyl]phenyl}propanoic acid (+/-)-2-[4-(2-Oxocyclohexylidenemethyl)phenyl]propionic acid (±)-p-[[(E)-2-Oxocyclohexylidene]methyl]hydratropic Acid Pelubiprofen Pelubiprofen (JAN/INN) 2-[4-(2-oxo-1-cyclohexylidenemethyl)phenyl]propionic acid MFCD00870907

Description	Pelubiprofen, an orally active and non-steroidal anti-inflammatory drug, is a member of the 2-arylpropionic acid family and has relatively selective effects on COX-2 activity. Pelubiprofen inhibits COX activity and the transforming growth factor-β activated kinase 1-IκB kinase β-NF-κB pathway, and has significant anti-inflammatory and analgesic effects[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> COX
Target	COX-2
References	[1]. Choi IA, Baek HJ, et al. Comparison of the efficacy and safety profiles of a pelubiprofen versus celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, phase III, non-inferiority clinical trial. BMC Musculoskelet Disord. 2014 Nov 18;15:375.

670-80-4

43153-04-4

69956-77-0