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107257-28-3

107257-28-3 structure
107257-28-3 structure
  • Name: PK14105
  • Chemical Name: N-butan-2-yl-1-(2-fluoro-5-nitrophenyl)-N-methylisoquinoline-3-carboxamide
  • CAS Number: 107257-28-3
  • Molecular Formula: C21H20FN3O3
  • Molecular Weight: 381.40000
  • Catalog: Research Areas Others
  • Create Date: 2016-02-09 14:35:18
  • Modify Date: 2024-01-11 15:00:54
  • PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.in vivo binding experiments, in which PK 14105 was injected into rats with unilaterallylesioned striata, demonstrate that PK 14105 rapidly crosses the blood-brain-barrier and that thereis a marked retention of radioactivity in the lesioned striatum not seen in the unlesioned striatum or cerebellar vermis[1]It can also inhibit receptor ligands, calcium channel ligands and co-transporter in all salivary glands. [2]

Name N-butan-2-yl-1-(2-fluoro-5-nitrophenyl)-N-methylisoquinoline-3-carboxamide
Synonyms 3-Isoquinolinecarboxamide,1-(2-fluoro-5-nitrophenyl)-N-methyl-N-(1-methylpropyl)
PK14105
Description PK14105 is a biological evaluation as a potential radioligand for PET studies of PBBS receptors.in vivo binding experiments, in which PK 14105 was injected into rats with unilaterallylesioned striata, demonstrate that PK 14105 rapidly crosses the blood-brain-barrier and that thereis a marked retention of radioactivity in the lesioned striatum not seen in the unlesioned striatum or cerebellar vermis[1]It can also inhibit receptor ligands, calcium channel ligands and co-transporter in all salivary glands. [2]
Related Catalog
References

[1]. Pascali C et al. The radiosynthesis of [18F]PK 14105 as an alternative radioligand for peripheral type benzodiazepine binding sites. Int J Rad Appl Instrum A. 1990;41(5):477-82.

[2]. Franklin C. Wong et al. Affinity Labeling of Membrane Receptors Using Tissue-Penetrating Radiations. Biomed Res Int. 2013, 503095.

Density 1.257g/cm3
Boiling Point 555.7ºC at 760mmHg
Molecular Formula C21H20FN3O3
Molecular Weight 381.40000
Flash Point 289.9ºC
Exact Mass 381.14900
PSA 79.02000
LogP 5.34280
Vapour Pressure 2.18E-12mmHg at 25°C
Index of Refraction 1.612
Storage condition 2-8℃