127290-60-2

127290-60-2 structure

Name: L-Isoleucine-d1
Chemical Name: (2S,3Ξ)-2-amino-2-deuterio-3-methyl-pentanoic acid
CAS Number: 127290-60-2
Molecular Formula: C₆H₁₂DNO₂
Molecular Weight: 132.18
Create Date: 2017-06-16 17:42:12
Modify Date: 2024-01-10 17:28:00
L-Isoleucine-d1 is the deuterium labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.

Name	(2S,3Ξ)-2-amino-2-deuterio-3-methyl-pentanoic acid
Synonyms	L-ISOLEUCINE-2-D1 α-Deutero-isoleucin

Description	L-Isoleucine-d1 is the deuterium labeled L-Isoleucine. L-isoleucine is a nonpolar hydrophobic amino acid[1]. L-Isoleucine is an essential amino acid.
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Arkhipov SG, et al. New hydrophobic L-amino acid salts: maleates of L-leucine, L-isoleucine and L-norvaline. Acta Crystallogr C Struct Chem. 2015 Jul;71(Pt 7):584-92.