107910-75-8
107910-75-8 structure
- Name: Ganciclovir sodium
- Chemical Name: Ganciclovir sodium
- CAS Number: 107910-75-8
- Molecular Formula: C9H12N5NaO4
- Molecular Weight: 277.212
- Catalog: API Synthetic anti-infective drugs Antiviral drugs
- Create Date: 2018-07-14 12:25:06
- Modify Date: 2024-01-10 17:33:15
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Ganciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3].
| Name | Ganciclovir sodium |
|---|---|
| Synonyms |
Sodium 2-amino-9-{[(1,3-dihydroxy-2-propanyl)oxy]methyl}-6-oxo-6,9-dihydropurin-1-ide
Ganciclovir Sodium Salt sodium 2-amino-9-{[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl}-9h-purin-6-olate Cymevene Ganciclovir monosodium salt 1,3-propanediol, 2-[(2-amino-6-hydroxy-9H-purin-9-yl)methoxy]-, monosodium salt 2-amino-9-{[2-hydroxy-1-(hydroxyméthyl)éthoxy]méthyl}-9H-purin-6-olate de sodium 6H-Purin-6-one, 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-, sodium salt (1:1) Ganciclovir sodium Unii-02L083W284 |
| Description | Ganciclovir (BW 759) sodium, a nucleoside analogue and an orally active antiviral agent, shows activity against CMV. Ganciclovir sodium also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir sodium inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir sodium has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1)[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
CMV HSV-1 HSV-2 FHV-1:5.2 μM (IC50) |
| In Vitro | Ganciclovir sodium is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 mumol versus 72 mumol for acyclovir[4].The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'-triphosphate (ganciclovir-TP). This inhibition includes a selective and potent inhibition of the viral DNA polymerase. Ganciclovir sodium is metabolized to the triphosphate form by primarily three cellular enzymes: a deoxyguanosine kinase induced by CMV-infected cells; guanylate kinase; and phosphoglycerate kinase[5]. |
| In Vivo | Ganciclovir sodium (1-80 mg/kg; i.h.; daily for 5 days) delays MCMV-induced wasting syndrome and mortality[6]. Animal Model: Severe combined immunodeficiency (SCID) mice (MCMV infection)[6] Dosage: 1-80 mg/kg Administration: I.h.; daily for 5 days Result: Dose dependently delayed MCMV-induced wasting syndrome and mortality. |
| References |
| Density | 1.81g/cm3 |
|---|---|
| Boiling Point | 675ºC at 760mmHg |
| Melting Point | 250ºC (decomposition) |
| Molecular Formula | C9H12N5NaO4 |
| Molecular Weight | 277.212 |
| Flash Point | 362ºC |
| Exact Mass | 277.078705 |
| PSA | 142.37000 |
| Storage condition | -20℃ |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
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| HS Code | 2933990090 |
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| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |