477-17-8

477-17-8 structure

Name: Hippeastrine
Chemical Name: hippeastrine
CAS Number: 477-17-8
Molecular Formula: C₁₇H₁₇NO₅
Molecular Weight: 315.32100
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2016-03-10 01:51:13
Modify Date: 2024-01-20 16:25:16
Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities[1].

Name	hippeastrine
Synonyms	Hippeastrine

Description	Hippeastrine, an active alkaloid, exhibits a good dose-dependent inhibitory effect against topoisomerase I (Top I) with an IC50 at 7.25 μg/mL. Antiproliferative and anticancer activities[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
In Vitro	Hippeastrine strongly inhibits the proliferation of HT-29 and Hep G2 cells in an intuitive dose-dependent manner with the IC50s at 3.98 μg/mL and 11.85 μg/mL, respectively, and also induces significant cellular morphological changes, which further validate our screening method and the potent antineoplastic effects[1].
References	[1]. Chen GL, et al. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I. Sci Rep. 2016;6:38284. Published 2016 Dec 6.