38482-71-2

38482-71-2 structure

Name: leucyl-arginyl-prolyl-glycinamide
Chemical Name: (2S)-1-[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
CAS Number: 38482-71-2
Molecular Formula: C₁₉H₃₆N₈O₄
Molecular Weight: 440.54000
Catalog: Signaling Pathways GPCR/G Protein GNRH Receptor
Create Date: 2016-03-19 06:10:24
Modify Date: 2024-01-07 20:06:27
LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes[3].

Name	(2S)-1-[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-(2-amino-2-oxoethyl)pyrrolidine-2-carboxamide
Synonyms	Glycinamide,L-leucyl-L-arginyl-L-prolyl Lapg-NH2 Leucyl-arginyl-prolyl-glycinamide

Description	LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes[3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology
In Vitro	The formation of LHRH 4-10, LHRH 7-10, and LHRH 6-10Co-incubation are inhibited by known enzyme inhibitors including Captopril (HY-B0368) (an ACE inhibitor), Thiorphan (HY-W013375) (an EP24.11 inhibitor), and Ethylenediaminetetraacetic acid (HY-Y0682) (an EP24.15 inhibitor)[3]. LH-RH (7-10) inhibits the binding of 125I-labeled GnRH to monoclonal antibody P81662 with an IC50 value of 1.7 nM[4].
In Vivo	LH-RH (7-10) (i.v.) increases esterase activity in plasma kinin system in rats[1]. LH-RH (7-10) (ntracarotid infusion i.v.; single dose) stimulates a significant increase in plasma LH concentration in the jugular vein[2]. Animal Model: New Zealand White Rabbit[2] Dosage: 100, 500 and 2500 ng dissolved in 0-9% (w/v) NaCl solution and diluted Administration: Ntracarotid infusion; infused with a constant volume of 7-5 mL per 30 min Result: Caused LH release in the female rabbit during various reproductive conditions.