51025-85-5

51025-85-5 structure

Name: HBK
Chemical Name: arbekacin
CAS Number: 51025-85-5
Molecular Formula: C₂₂H₄₄N₆O₁₀
Molecular Weight: 552.619
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-06-01 08:00:00
Modify Date: 2024-01-07 00:55:58
Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria[1].

Name	arbekacin
Synonyms	AHB-DKB HBK HABA-DKB MFCD00864919 4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide (S)-O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1®6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-erythrohexopyranosyl-(1®4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine 3-AMINO-2-METHOXY-4-PICOLINE 1-N-[(S)-4-Amino-2-hydroxybutyryl]-3',4'-dideoxykanamycin B Haberacin Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy- Arbekacin 1-N-[(S)-4-Amino-2-hydroxybutyryl]dibekacin

Description	Arbekacin, an aminoglycoside antibiotic, exhibits broad antimicrobial activities against not only Gram-positive bacteria but also Gram-negative bacteria[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Arbekaci 有效抑制鲍氏不动杆菌 (MIC50=2 μg/mL) 和来自 PHP 的肠杆菌科 (MIC50=0.25-2 μg/mL; MIC90=1-8 μg/mL)[1]。 Arbekacin 也抑制全球范围内特征明确的耐多药革兰氏阴性和 MRSA 菌株[1]。
References	[1]. Matsumoto T. Arbekacin: another novel agent for treating infections due to methicillin-resistant Staphylococcus aureus and multidrug-resistant Gram-negative pathogens. Clin Pharmacol. 2014 Sep 26;6:139-48. [2]. Sader HS, et al. Arbekacin activity against contemporary clinical bacteria isolated from patients hospitalized with pneumonia. Antimicrob Agents Chemother. 2015;59(6):3263-70.