82993-43-9

82993-43-9 structure

Name: Lewis y tetrasaccharide
Chemical Name: LewisYtetrasaccharide
CAS Number: 82993-43-9
Molecular Formula: C₂₆H₄₅NO₁₉
Molecular Weight: 675.63100
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FAK
Create Date: 2016-02-13 05:01:48
Modify Date: 2024-01-03 11:52:15
Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].

Name	LewisYtetrasaccharide

Description	Lewis Y tetrasaccharide (Lewis Y, LeY) is a tetrasaccharide derivative form of Lewis X trisaccharide (HY-N10534). Lewis Y tetrasaccharide is an antigen associated with malignant ovarian carcinomas metastasis and poor prognosis[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FAK
In Vitro	Lewis Y tetrasaccharide activates FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression to enhance cell adhesion mediated drug resistance (CAM-DR) in ovarian cancer cells[1]. Lewis Y tetrasaccharide results in integrin α5β1 level increase in ovarian carcinoma-derived cells exhibiting enhanced expression of LeY (RMG-1-hFUT)[2]. Lewis Y tetrasaccharide enhances the adhesive and spreading potentials mediated by the integrin-fibronectin interaction of ovarian carcinoma RMG-1 cells[2]. Anti-LeY antibodies (10 μg/mL; 37 ℃; 24 h) significantly inhibits the proliferation and adhesion ability of RMG-1-hFUT cells cultured in vivo[2].
References	[1]. Yan LM, et al. Enhancement of the adhesive and spreading potentials of ovarian carcinoma RMG-1 cells due to increased expression of integrin alpha5beta1 with the Lewis Y-structure on transfection of the alpha1,2-fucosyltransferase gene. Biochimie. 2010 Jul;92(7):852-7. [2]. Yan L, et al. Lewis y enhances CAM-DR in ovarian cancer cells by activating the FAK signaling pathway and upregulating Bcl-2/Bcl-XL expression. Biochimie. 2015 Jun;113:17-25.