185376-97-0
185376-97-0 structure
- Name: RS 102221 hydrochloride
- Chemical Name: RS 102221 hydrochloride,8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dionehydrochloride
- CAS Number: 185376-97-0
- Molecular Formula: C27H32ClF3N4O7S
- Molecular Weight: 612.618
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-02-18 08:00:00
- Modify Date: 2024-01-08 08:15:59
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RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats[1][2].
| Name | RS 102221 hydrochloride,8-[5-(2,4-Dimethoxy-5-(4-trifluoromethylphenylsulphonamido)phenyl-5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dionehydrochloride |
|---|---|
| Synonyms |
N-{5-[5-(2,4-Dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)pentanoyl]-2,4-dimethoxyphenyl}-4-(trifluoromethyl)benzenesulfonamide
RS-102221 Benzenesulfonamide, N-[5-[5-(2,4-dioxo-1,3,8-triazaspiro[4.5]dec-8-yl)-1-oxopentyl]-2,4-dimethoxyphenyl]-4-(trifluoromethyl)- |
| Description | RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats[1][2]. |
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| Related Catalog | |
| Target |
5-HT2C Receptor:10 nM (Ki) 5-HT2A Receptor 5-HT2B Receptor |
| In Vitro | RS102221 (0.3-300nM; 24 h) 促进小鼠成年海马神经前体细胞 (ahNPCs) 分化，并显著增加 MAP-2+ 细胞的百分比[1]。 Cell Differentiation Assay[1] Cell Line: Mouse adult hippocampal neural progenitor cells (ahNPCs) Concentration: 0.3, 1, 10, 30, 100, and 300 nM Incubation Time: 24 hours Result: Significantly increases the percentage of MAP-2+ cells at 10 nM. |
| In Vivo | RS-102221 (2 mg/kg; 腹腔注射; 每天 1 次, 共 14 天) 增加大鼠的食物摄入量和体重增加[2]。 RS-102221 (2 mg/kg; 腹腔注射; 单次剂量) 与 3,4-亚甲基二氧基-N-甲基苯丙胺 (MDMA 或“摇头丸”) 联合施用于小鼠，可在前 1 小时抑制 MDMA 诱导厌食症，和 MDMA 诱导的过度运动[3]。 RS-102221 (2 mg/kg; 腹腔注射; 单次剂量) 可减轻小鼠在光暗试验中的焦虑，并降低惊吓反射的幅度[4]。 |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 753.5ºC at 760 mmHg |
| Molecular Formula | C27H32ClF3N4O7S |
| Molecular Weight | 612.618 |
| Flash Point | 409.5ºC |
| Exact Mass | 612.186584 |
| PSA | 151.52000 |
| LogP | 3.75 |
| Vapour Pressure | 4.8E-23mmHg at 25°C |
| Index of Refraction | 1.604 |