Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SR-95531
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Gabazine (SR-95531)
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

104104-50-9

104104-50-9 structure

104104-50-9 structure

Name: SR-95531
Chemical Name: 2-(3-carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium bromide
CAS Number: 104104-50-9
Molecular Formula: C₁₅H₁₈BrN₃O₃
Molecular Weight: 368.226
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-08-04 11:41:16
Modify Date: 2024-01-06 14:02:15
Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor.

Name	2-(3-carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium bromide
Synonyms	MFCD00055135 4-[6-Imino-3-(4-methoxyphenyl)pyridazin-1(6H)-yl]butanoic acid hydrobromide (1:1) Pyridazinium, 6-amino-1-(3-carboxypropyl)-3-(4-methoxyphenyl)-, bromide (1:1) 6-Amino-1-(3-carboxypropyl)-3-(4-methoxyphenyl)pyridazin-1-ium bromide 2-(3-carboxypropyl)-6-(4-methoxyphenyl)pyridazin-3(2H)-iminium bromide Gabazine SR-95531

Description	Gabazine is a selective and competitive antagonist of GABAA receptor, with an IC50 of ~0.2 μM for GABA receptor.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease
Target	0.2 μM (GABA receptor)[1].
In Vitro	Both bicuculline and Gabazine (SR 95531) have been characterized as competitive inhibitors of GABA binding to the GABAA receptor. Gabazine is more potent than bicuculline at blocking currents elicited by GABA, with an IC50 for currents elicited by 3 μM GABA of ~0.2 μM and a Hill coefficient of 1.0. Gabazine reduces the currents elicited by 10 μM alphaxalone by ~30%, for responses of receptors containing wildtype β2 subunits. The concentration of Gabazine requires producing half the maximal block is ~0.2 μM. Gabazine also could only produce a partial block of currents gated by 300 μM pentobarbital. The maximal reduction, again, is ~30%, and the concentration of Gabazine required to produce half the maximal block is ~0.15 μM[1].
References	[1]. Ueno S, et al. Bicuculline and gabazine are allosteric inhibitors of channel opening of the GABAA receptor. J Neurosci. 1997 Jan 15;17(2):625-34.

Boiling Point	474.4ºC at 760 mmHg
Melting Point	200 ºC (ethanol )
Molecular Formula	C₁₅H₁₈BrN₃O₃
Molecular Weight	368.226
Flash Point	240.7ºC
Exact Mass	367.053131
PSA	89.32000
Appearance	solid white
Vapour Pressure	8.33E-10mmHg at 25°C
Storage condition	Store at RT
Water Solubility	DMSO: 30 mg/mL

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3