147523-65-7

147523-65-7 structure

Name: LY 288513
Chemical Name: LY 288513,(4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide
CAS Number: 147523-65-7
Molecular Formula: C₂₂H₁₈BrN₃O₂
Molecular Weight: 436.30100
Catalog: Signaling Pathways GPCR/G Protein Cholecystokinin Receptor
Create Date: 2017-08-18 18:24:47
Modify Date: 2024-01-09 16:51:25
LY288513, a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 possesses both anxiolytic and antipsychotic potential[1][2][3].

Name	LY 288513,(4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide

Description	LY288513, a selective non-peptide CCK-B receptor antagonist with an IC50 value of 16 nM. LY288513 possesses both anxiolytic and antipsychotic potential[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Cholecystokinin Receptor Research Areas >> Neurological Disease
Target	IC50: 16 nM (CCK-B receptor)[1]
In Vitro	LY288513 (10 nM; 2 days) suppresses the effects of CCK-8 on CD4+ T cell subset-specific transcription factors[2]. RT-PCR[2] Cell Line: CD4+ T cells Concentration: 10 nM Incubation Time: 2 days Result: Suppressed the effects of CCK-8 on CD4+ T cell subset-specific transcription factors.
In Vivo	LY288513 (3, 10 mg/kg, i.p.; 10, 30 mg/kg, p.o.) produces an anxiolytic-like action[3]. LY288513 (1000 mg/kg, p.o.) potentiates the effects of a CNS depressant, slightly lowered body temperature, and had modest sedative effects only at the highest dose examined[3]. Animal Model: Male CD-l mice[3] Dosage: 3, 10 mg/kg; 10, 30 mg/kg Administration: I.p.; p.o. Result: Displayed anxiolytic-like effects in the elevated plusmaze.
References	[1]. Rasmussen K. CCK, schizophrenia, and anxiety. CCK-B antagonists inhibit the activity of brain dopamine neurons. Ann N Y Acad Sci. 1994 Mar 23;713:300-11. [2]. Zhang JG, et al. Cholecystokinin octapeptide regulates the differentiation and effector cytokine production of CD4(+) T cells in vitro. Int Immunopharmacol. 2014;20(2):307-315. [3]. Helton DR, et al. Central nervous system characterization of the new cholecystokininB antagonist LY288513. Pharmacol Biochem Behav. 1996 Mar;53(3):493-502.

Density	1.476g/cm3
Molecular Formula	C₂₂H₁₈BrN₃O₂
Molecular Weight	436.30100
Exact Mass	435.05800
PSA	61.44000
LogP	5.19260
Index of Refraction	1.676

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