170856-41-4

170856-41-4 structure

Name: PNU 96415E
Chemical Name: 1-[2-(3,4-dihydro-1H-isochromen-1-yl)ethyl]-4-(4-fluorophenyl)piperazine,dihydrochloride
CAS Number: 170856-41-4
Molecular Formula: C₂₁H₂₇Cl₂FN₂O
Molecular Weight: 413.35600
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-01-09 05:45:33
Modify Date: 2024-04-03 20:57:00
PNU-96415E is a selective D4/5-HT2A antagonist. PNU-96415E may have potential antipsychotic efficacy[1].

Name	1-[2-(3,4-dihydro-1H-isochromen-1-yl)ethyl]-4-(4-fluorophenyl)piperazine,dihydrochloride

Description	PNU-96415E is a selective D4/5-HT2A antagonist. PNU-96415E may have potential antipsychotic efficacy[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	D4 Receptor 5-HT2A Receptor
In Vivo	PNU-96415E blockes 5-HTP-induced bead twitches in mice and stereotypic behaviours produced by high doses of amphetamine and methylphenidate[1].
References	[1]. Kulkarni SK, et al. Dopamine D4 receptors and development of newer antipsychotic drugs. Fundam Clin Pharmacol. 2000;14(6):529-539.