1795786-02-5

1795786-02-5 structure

Name: (R)-Linezolid-d3
Chemical Name: (R)-Linezolid-d3
CAS Number: 1795786-02-5
Molecular Formula: C₁₆H₁₇D₃FN₃O₄
Molecular Weight: 340.365
Catalog: Research Areas Infection
Create Date: 2016-04-17 20:14:55
Modify Date: 2024-01-02 18:42:24
(R)-Linezolid-d3 ((R)-PNU-100766-d3) is the deuterium labeled (R)-Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis[1][2].

Name	(R)-Linezolid-d3
Synonyms	Acetamide-d, N-[[(5R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]- N-({(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)(H)acetamide

Description	(R)-Linezolid-d3 ((R)-PNU-100766-d3) is the deuterium labeled (R)-Linezolid. (R)-Linezolid is an impurity of Linezolid (PNU-100766). Linezolid, the first member of the class of oxazolidinone synthetic antibiotic, acts by inhibiting the initiation of bacterial protein synthesis[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Bednarek E, et al. NMR and molecular modeling study, as complementary techniques to capillary electrophoresis method to elucidate the separation mechanism of linezolid enantiomers. J Chromatogr A. 2008 Jun 6;1193(1-2):164-71. [3]. Clemett D, et al. Linezolid. Drugs. 2000 Apr;59(4):815-27; discussion 828.