733717-87-8

733717-87-8 structure

Name: SCH 50911
Chemical Name: sch 50,911
CAS Number: 733717-87-8
Molecular Formula: C₈H₁₅NO₃
Molecular Weight: 173.21000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-06-15 01:38:29
Modify Date: 2024-01-27 13:22:41
SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

Name	sch 50,911
Synonyms	SCH-50911 Sch 50911 (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid (2S)-(+)-5,5-dimethyl-2-morpholineacetic acid SCH 50911 (2S)-5,5-dimethyl-2-morpholineacetic acid WS 3

Description	SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	GABA(B):1.1 μM (IC50)
References	[1]. Ong J, et al. The morpholino-acetic acid analogue Sch 50911 is a selective GABA(B) receptor antagonist in rat neocortical slices. Eur J Pharmacol. 1998 Nov 27;362(1):35-41.