152831-36-2

152831-36-2 structure

Name: NE 10790
Chemical Name: 2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid
CAS Number: 152831-36-2
Molecular Formula: C₈H₁₀NO₆P
Molecular Weight: 247.14200
Catalog: Research Areas Others
Create Date: 2018-05-14 19:37:19
Modify Date: 2025-09-18 09:34:30
NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.

Name	2-hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid
Synonyms	3-PEHPC 3-(3-pyridyl)-2-hydroxy-2-phosphonopropanoic acid NE-10790 2-hydroxy-2-phosphono-3-pyridin-3-ylpropanoic acid 2-hydroxy-2-phosphono-3-(3-pyridyl)propionic acid

Description	NE 10790, a poor farnesyl pyrophosphate synthase inhibitor, is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak antiresorptive agent.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	FPP synthase[1].
In Vitro	NE 10790 inhibits incorporation of [14C]mevalonic acid into Rab6, but not into H-Ras or Rap1, proteins that are modified by FTase and GGTase I, respectively. NE 10790 reduces viability in J774 cells. NE 10790 prevents prenylation of 22-26-kDa proteins that are not modified by FTase or GGTase I[1].
References	[1]. Coxon FP, et al. Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages. J Biol Chem. 2001 Dec 21;276(51):48213-22.