40842-04-4

40842-04-4 structure

Name: Bis-propargyl-PEG1
Chemical Name: ethylene glycol dipropargyl ether
CAS Number: 40842-04-4
Molecular Formula: C₈H₁₀O₂
Molecular Weight: 138.16400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-01-20 20:48:49
Modify Date: 2024-01-14 18:28:43
Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	ethylene glycol dipropargyl ether
Synonyms	1-2 bis 2 propynyloxy ethane 1,2-bis(propargyloxy)ethane 1,2-di(2-propynyloxy)ethane 1,2-di-propargyloxyethane 1,2-dipropargyloxyethane 1,2-bis-prop-2-ynyloxy-ethane

Description	Bis-propargyl-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562