448954-98-1

448954-98-1 structure

Name: NH2-O-C5-COOH hydrobromide
Chemical Name: 6-aminooxyhexanoic acid,hydrobromide
CAS Number: 448954-98-1
Molecular Formula: C₆H₁₄BrNO₃
Molecular Weight: 228.08400
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-23 12:53:38
Modify Date: 2024-01-05 22:37:34
NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	6-aminooxyhexanoic acid,hydrobromide
Synonyms	6-Aminooxy-hexanoic acid hydrobromide 6-Aminooxy-hexanoic acid Hexanoicacid,6-(aminooxy)-,hydrobromide (1:1)

Description	NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562