143839-74-1

143839-74-1 structure

Name: L685818
Chemical Name: l-685,818
CAS Number: 143839-74-1
Molecular Formula: C₄₃H₆₉NO₁₃
Molecular Weight: 808.00700
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-03-13 05:09:24
Modify Date: 2024-04-05 18:10:56
L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans[1][2].

Name	l-685,818
Synonyms	l-685818 l-685818

Description	L685818 is a specific immunophilin ligand. L685818 was neuroregenerative and non-neuroprotective in primary brain cultures. L685818 protects dopaminergic neurons from toxic inhibition of MPP+ and 6-OHDA, reduces tyrosine hydroxylase (TH) loss, and promotes neuronal process regeneration. L685818 is also an antifungal reagent for Cryptococcus neoformans[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Neurological Disease
In Vitro	L685818 (100 nM; MPP+ 组处理 2 天, 6-OHDA组处理 24 h) 具有神经保护作用，在 MPP+ 和 6-OHDA 抑制下，增加 TH+ 细胞的数目[1]。 L685818 (10-100 nM; 24 h) 防止 MPP+ 和 6-OHDA (HY-B1081) 处理引起的酪氨酸羟化酶 (TH) 损失[1]。 L685818 (0.01-1 μM; 24 h) 防止 MPP+ 和 6-OHDA 导致神经元突起的收缩和丢失，促进突起再生[1]。
References	[1]. Guo X, et al. Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons. Eur J Neurosci. 2001 May;13(9):1683-93. [2]. Odom A, et al. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrob Agents Chemother. 1997 Jan;41(1):156-61.