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124811-87-6

124811-87-6 structure
124811-87-6 structure
  • Name: ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
  • Chemical Name: ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
  • CAS Number: 124811-87-6
  • Molecular Formula: C14H15NO4
  • Molecular Weight: 261.27300
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2018-04-29 23:57:04
  • Modify Date: 2025-08-27 11:05:14
  • Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1].

Name ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
Synonyms 2-(4-methoxy-phenyl)-5-methyl-oxazole-4-carboxylic acid ethyl ester
ethyl 5-methyl-2-(4-methoxy)phenyl-4-oxazolecarboxylate
2-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole
Description Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1].
Related Catalog
In Vitro Anticancer agent 73 (compound CIB-3b) (10 μM; 6 hours) increases the expression of E-cadherin and decreases the protein expression levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells; inhibits the proliferation and migration of SK-HEP-1, HCCLM3 and MHCC97L cells by inhibiting miRNA biogenesis[1].
In Vivo Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) attenuates the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice[1]
References

[1]. Peng T, et al. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem. 2022 Jun 13.

Molecular Formula C14H15NO4
Molecular Weight 261.27300
Exact Mass 261.10000
PSA 61.56000
LogP 2.83530
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