124811-87-6

124811-87-6 structure

Name: ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
Chemical Name: ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
CAS Number: 124811-87-6
Molecular Formula: C₁₄H₁₅NO₄
Molecular Weight: 261.27300
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-04-29 23:57:04
Modify Date: 2024-01-04 20:06:07
Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1].

Name	ethyl 2-(4-methoxyphenyl)-5-methyloxazole-4-carboxylate
Synonyms	2-(4-methoxy-phenyl)-5-methyl-oxazole-4-carboxylic acid ethyl ester ethyl 5-methyl-2-(4-methoxy)phenyl-4-oxazolecarboxylate 2-(4-Methoxyphenyl)-4-carbethoxy-5-methyloxazole

Description	Anticancer agent 73 (compound CIB-3b) is a anticancer agent, potently targeting TAR RNA-binding protein 2 (TRBP) and disrupts its interaction with Dicer. Anticancer agent 73 can rebalance the expression profile of oncogenic or tumor-suppressive miRNAs. Anticancer agent 73 suppresses the proliferation and metastasis of HCC in vitro and in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Anticancer agent 73 (compound CIB-3b) (10 μM; 6 hours) increases the expression of E-cadherin and decreases the protein expression levels of fibronectin, N-cadherin, and vimentin in SK-HEP-1 cells; inhibits the proliferation and migration of SK-HEP-1, HCCLM3 and MHCC97L cells by inhibiting miRNA biogenesis[1].
In Vivo	Anticancer agent 73 (10, 25 and 50 mg/kg; IV, every 2 days for 4 weeks) attenuates the proliferation and migration of SK-HEP-1 and SK-HEP-1 implanted in SCID mice[1]
References	[1]. Peng T, et al. Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis. J Med Chem. 2022 Jun 13.