79781-00-3

79781-00-3 structure

Name: Bulaquine
Chemical Name: ablaquine
CAS Number: 79781-00-3
Molecular Formula: C₂₁H₂₇N₃O₃
Molecular Weight: 369.45700
Catalog: Research Areas Infection
Create Date: 2018-05-12 17:49:11
Modify Date: 2024-01-18 20:11:25
Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3].

Name	ablaquine
Synonyms	N1-(3-Acetyl-4,5-dihydrofuran-2-yl)-N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine

Description	Bulaquine (CDRI 80/53) is a potent antimalarial agent which is an analogue of Primaquine (HY-12651A). Bulaquine affects multiple metabolism pathways and shows inhibition effect on Plasmodium cynomolgi infection. Bulaquine can be used for the research of malaria[1][2][3].
Related Catalog	Research Areas >> Infection
In Vivo	Bulaquine (40 mg/kg; p.o. once) affects multiple pathways in vivo[1]. Bulaquine (1.25 mg/kg; once daily; for 7 days) shows 100% curative anti-relapse activity with a primaquine index of 0.8 for rhesus monkeys with Plasmodium cynomolgi B infection[2]. Animal Model: 25-30 g male Swiss albino mice[1] Dosage: 40 mg/kg Administration: Oral gavage; 40 mg/kg once Result: Affected oxidative stress and fatty acid synthesis pathway, apoptosis, cell cycle, inflammatory response, glycogen metabolism, Kreb’s cycle, electron transport chain, fatty acid β-oxidation, MAPK signalling, signalling of hepatocyte growth factor receptor, matrix metalloproteinases, steroid biosynthesis, TGF-β signalling, translation factors, Wnt signalling, regulation of actin cytoskeleton, ribosomal proteins, RNA transcription reactome, proteasome degradation and nuclear receptors in lipid metabolism according to GO results.