140405-36-3
140405-36-3 structure
- Name: RSVA 405
- Chemical Name: N'-[1-(4-diethylamino-2-hydroxyphenyl)methylidene]isonicotinohydrazide
- CAS Number: 140405-36-3
- Molecular Formula: C17H20N4O2
- Molecular Weight: 312.36600
- Create Date: 2018-05-14 01:53:58
- Modify Date: 2024-04-09 18:37:11
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RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 also can be used for the research of obesity.
| Name | N'-[1-(4-diethylamino-2-hydroxyphenyl)methylidene]isonicotinohydrazide |
|---|---|
| Synonyms |
p-(N,N-diethylamino)salicylaldehyde isonicotinoylhydrazone
N'-[4-(diethylamino)-2-hydroxybenzylidene]isonicotinohydrazide Hit2Lead 5113025 ST 91 |
| Molecular Formula | C17H20N4O2 |
|---|---|
| Molecular Weight | 312.36600 |
| Exact Mass | 312.15900 |
| PSA | 77.82000 |
| LogP | 2.78820 |