26057-70-5

26057-70-5 structure

Name: Avenaciolide
Chemical Name: (+/-)-avenaciolide
CAS Number: 26057-70-5
Molecular Formula: C₁₅H₂₂O₄
Molecular Weight: 266.33300
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-05-23 12:22:16
Modify Date: 2024-01-08 16:18:36
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].

Name	(+/-)-avenaciolide
Synonyms	dl-Avenaciolid dl-avenaciolide (3aR,4R,6aR)-3-Methylene-4-octyl-dihydro-furo[3,4-b]furan-2,6-dione (+-)-Avenaciolid

Description	Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Castelo-Branco PA, et al. Synthesis and antifungal activity of aromatic bis-gamma-lactones analogous to avenaciolide. Chem Biodivers. 2007;4(12):2745-2754. [2]. McGivan JD, Chappell JB. Avenaciolide: a specific inhibitor of glutamate transport in rat liver mitochondria. Biochem J. 1970;116(4):37P-38P.